Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair

Effect of Zeolite and Zeolite/Collagen nanocomposite scaffolds on healing of segmental femur bone defect in rabbits

Objective- The present study was aimed to evaluate repair of a critical segmental defect of rabbit femur using the rabbit’s femoral defects repaired by Zeolite and Zeolite/Collagen scaffolds Design- Experimental Study Animals- Forty-five mature male New Zealand white rabbits Procedures- The animals were randomly divided into three groups of 15 animals each. In the first group...

Evaluation of the Repair of Bone Defect after Bone Marrow Stromal Cell Transplantation in Rat

Background & Objective: Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSC transplantation for the repair of bone defects in the rat.   Materials & Methods : Twenty-eight male adult rats were divided into 4 groups. Group 1 ( control group) received no treatment after the...

Biomimetic biphasic scaffolds for osteochondral defect repair

The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structure...

Novel peptide-based biomaterial scaffolds for tissue engineering.

Biomaterial scaffolds are components of cell-laden artificial tissues and transplantable biosensors. Some of the most promising new synthetic biomaterial scaffolds are composed of self-assembling peptides that can be modified to contain biologically active motifs. Peptide-based biomaterials can be fabricated to form two- and three-dimensional structures. Recent studies show that biomaterial pro...

BMP-2 Gene & Cell-functionalized 3D Scaffolds for the Repair of Cranial Bone Defect